Mechanisms of glyceraldehyde 3-phosphosphate dehydrogenaseis in bacteria adhesion-A review

Abstract:

Glyceraldehyde 3-phosphosphate dehydrogenaseis (GAPDH) acts as an enzymes of glycolysis and participates in the glycolytic pathway to generate energy. As a "housekeeping" protein, GAPDH is involved in many cellular processes in addition to glycolysis. These functions include DNA repair, tRNA export, facilitating microtubule polymerization, regulating the expression of the protein, and cell autophagy. Many researches indicated that bacterial surface GAPDH is involved in adhesion. This article reviews the basis function of GAPDH, and the role and mechanism of GAPDH in adhesion of bacteria.