Abstract:Foodborne pathogen infection is the primary factor causing foodborne diseases, which seriously endangers human health. Inflammasomes assemble multiprotein complexes by recognizing receptors to sense danger signals of invading pathogenic factors, thereby inducing inflammatory responses, which is an important defense line in the innate immune system. The NLRP3 inflammasome is an important intracellular inflammatory response platform that senses the invasion of pathogenic microorganisms and plays a crucial role in the innate immune response. Foodborne pathogen infection often causes abnormal activation of the NLRP3 inflammasome, which mediates the occurrence and development of a variety of inflammatory diseases. Therefore, the NLRP3 inflammasome is often taken as the target in the research on inflammation. In this review, we summarize the activation mechanisms of NLRP3 inflammasome by foodborne pathogens and their metabolites, as well as the mechanisms of natural products and dietary functional substances in inhibiting NLRP3 inflammasome activation, aiming to provide new ideas for the treatment of inflammatory diseases and the development of functional compounds that alleviate the inflammatory response induced by pathogenic bacteria.
