噬菌体治疗——旧概念, 新阶段

Bacteriophage therapy, old idea, new stage

摘要:

噬菌体治疗技术由来已久。噬菌体治疗的研究始于上世纪初, 之后由于抗生素的出现及其他原因在美国和西欧等国家中断。近年来, 全球范围的细菌耐药性使得科学家们重新审视和评估噬菌体治疗技术, 显示出巨大潜力。论述噬菌体发现历程及早期研究、人类及动物细菌感染的应用、噬菌体治疗与抗生素的不同之处、存在的问题等, 并探讨噬菌体技术可能的发展应用方向。

Abstract:

Bacteriophage therapy had been considered as an effective way for bacterial infection treatment for a long time. The research was started in the beginning of twenty century, but discontinued in America and Western Europe with the advent of antibiotics. Recently, scientists started to re-evaluate the bacteriophage therapy due to the worldwide bacteria resistance and found the great potential of phage-based prophylaxis and therapy of antibiotic-resistant bacterial infections. This paper reviews the history of bacteriophage therapy and the application in the treatment of human and animal bacterial in-fection, compares the difference between bacteriophage and antibiotics therapy and also discusses the existing problems and the future development of this technique.