Abstract:Research-based learning is an active learning mode designed to enhance students’ multiple abilities, aiming to stimulate learning interests, enhance self-directed learning and problem-solving skills, and foster teamwork awareness. It can effectively address issues such as the singularity of teaching objectives, lack of learning appeal, insufficient challenge, and limited intervention on poor study habits in traditional course teaching, encouraging students to shift from passive knowledge acceptance to independent exploration, and aligning with the talent training objectives of modern higher education. This paper summarizes the design philosophy, implementation plan, and key points of a research-based learning project applied in the teaching of Microbiology, based on the specific practice and the results of a follow-up questionnaire. The effectiveness of research-based learning in teaching practice is analyzed from the perspectives of the course, students and teachers. The results show that more than 85% of students recognize the positive improvement of their knowledge, abilities, and comprehensive literacy by research-based learning. Particularly, this project demonstrates satisfactory performance in enhancing learning abilities such as knowledge expansion and information mining, promoting cooperation and communication, and increasing interests in microbiology, with a sustainable improving effect.