Abstract:[Background] At present, carbonic anhydrase (CA) is applied in many fields such as medicine, natural active substance screening, biological detection, and carbon capture. Although a large number of related scientific papers and works have been published, there is still a lack of comprehensive and systematic bibliometric analysis of the research progress in CA. [Objective] To deeply explore and analyze the research trends, research hotspots, and development trends of CA that can be applied in carbon capture and provide research directions and data references for researchers engaged in related work. [Methods] The core collection of Web of Science (WOS) was selected as the data source. VOSviewer was used to analyze the keywords, number of publications, country distribution, author co-occurrence, and institution co-occurrence, thereby revealing the research hotspots and trends of CA. [Results] A total of 795 valid publications were ultimately selected. The United States ranked first in comprehensive cooperation among countries. China started relatively late in this field, but has shown rapid development in recent years and is currently ahead of other countries. From 2004 to 2023, the research hotspots of CA for carbon capture focused on the expression, function, and inhibitors of CA and CO2 capture. Over time, screening disease targets through molecular docking and modifying CA for carbon sequestration have become new research hotspots. [Conclusion] The application of CA in carbon capture has broad prospects. This article visually explains the research and development hotspots and trends of CA that can be used for carbon capture, providing a theoretical basis for the research and application of CA for carbon capture.