效应-免疫蛋白对所介导细菌接触依赖型拮抗作用研究进展

Research progress in bacterial contact-dependent antagonism mediated by effector-immunity pairs

摘要:

效应-免疫蛋白对(effector-immunity pairs, E-I pairs)在细菌的种间竞争中发挥重要作用，随着人们研究的不断深入和基因组数据的大量涌现，新鉴定的E-I pairs的数量正在快速增长，其多样性化的作用机制也不断地被报道。鉴于此，本文基于不同的细菌分泌系统，对E-I pairs所介导的细菌接触依赖型拮抗作用的最新研究进展进行综述，系统总结了接触依赖性生长抑制(contact-dependent growth inhibition, CDI)系统、VI型分泌系统(type VI secretion system, T6SS)和VII型分泌系统(type VII secretion system, T7SS)中的E-I pairs，简要介绍了未来该领域面临的挑战，旨在为进一步揭示E-I pairs细菌种间竞争中的作用研究提供新思路。

Abstract:

Effector-immunity pairs (E-I pairs) play a crucial role in interspecific competition among bacteria. As the research in this field advances and genomic data become increasingly available, increasing E-I pairs have been identified, and their diverse mechanisms of action have been reported. In light of this, this paper reviews the latest advancements in bacterial contact-dependent antagonism mediated by E-I pairs according to different bacterial secretion systems. It systematically summarizes the E-I pairs associated with the contact-dependent growth inhibition (CDI) system, type VI secretion system (T6SS), and type VII secretion system (T7SS), while briefing future challenges within this field. The objective of this review is to provide novel insights for elucidating the role of E-I pairs in bacterial interspecific competition.