热带假丝酵母在合成生物学中的研究进展及应用

Research progress and application of Candida tropicalis in synthetic biology

摘要:

热带假丝酵母(Candida tropicalis)是一种具有重要工业应用价值的非常规酵母，因其在长链二元酸和木糖醇的工业化应用而闻名。随着合成生物学的发展，热带假丝酵母在生物表面活性剂、单细胞油脂和高附加值化合物方面也展现出巨大的潜力，使其成为了生物技术应用的重点对象之一。本文综述了热带假丝酵母中遗传编辑工具开发和应用的最新研究进展，探讨了热带假丝酵母研究中的瓶颈及解决方案，为未来的研究提供了参考和助力，推动其在合成生物产业中的应用。

Abstract:

Candida tropicalis, an unconventional yeast species playing a significant role in industrial applications, is notable in the production of long-chain dicarboxylic acids and xylitol. With advancements in synthetic biology, C. tropicalis shows high potential as a host for producing biosurfactants, single-cell oil, and other high-value chemicals, becoming an important target in the application of biotechnology. This paper summarizes the recent progress in genome editing tools and applications in C. tropicalis and explores the bottlenecks and solutions in the research on C. tropicalis, aiming to provide reference for future research and drive forward the application of this yeast species in the industry of synthetic biology.