牙龈卟啉单胞菌铁/血红素摄取机制及利用的研究进展

Progress in iron/heme uptake mechanism and utilization of Porphyromonas gingivalis

摘要:

牙龈卟啉单胞菌(Porphyromonas gingivalis)是一种革兰氏阴性专性厌氧菌，是慢性牙周炎的关键病原体，并且与多种疾病相关。牙龈卟啉单胞菌作为一种缺乏铁载体的卟啉不良菌，主要以血红素的形式作为铁和原卟啉的来源。研究表明，牙龈卟啉单胞菌以Hmu铁/血红素摄取途径为主的多种途径摄取铁/血红素，并且在摄取铁/血红素后牙龈卟啉单胞菌可进一步通过利用铁/血红素增强其毒力。本文对牙龈卟啉单胞菌在铁/血红素摄取及利用方面的相关研究进行系统梳理，为牙周炎防治新策略的开发奠定了基础。

Abstract:

Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that has been implicated as the key pathogen of chronic periodontitis. Moreover, this bacterium is associated with various systemic diseases. P. gingivalis appears to lack siderophore and is a porphyrin auxotroph bacterium requiring heme as a source of iron and protoporphyrin. Studies have revealed that iron/heme uptake of P. gingivalis occurs by multiple pathways, mainly the Hmu iron/heme uptake pathway. P. gingivalis can enhance its virulence by utilizing iron/heme after iron/heme uptake. This paper systematically reviews the studies on iron/heme uptake and utilization by P. gingivalis to lay a foundation for developing new prevention and treatment strategies for periodontal diseases.