胆汁酸代谢调节肠道菌群在遗传性球形红细胞增多症合并胆汁淤积中的作用

Role of bile acid metabolism-gut microbiota interactions in hereditary spherocytosis associated with cholestasis

摘要:

遗传性球形红细胞增多症(hereditary spherocytosis, HS)是一种遗传性溶血性疾病，在全球范围内较为常见，临床上常表现为贫血、黄疸、脾大等。HS的诊断和治疗在近些年取得了显著进展，胆石症是其最为常见的并发症，严重影响患者身体健康。已有研究发现，HS合并胆汁淤积的患者存在胆汁酸代谢失衡的现象，并且胆汁酸代谢失衡又影响肠道菌群的组成和丰度。本研究就胆汁酸代谢调节肠道菌群在HS合并胆汁淤积中的作用机制进行综述，为HS合并胆汁淤积提供了治疗新策略。

Abstract:

Hereditary spherocytosis (HS) is a hereditary hemolytic disease with a global distribution, which often presents clinically with anemia, jaundice and splenomegaly. The diagnosis and treatment of HS has progressed significantly in recent years. Cholelithiasis is the most common complication, seriously affecting the health of HS patients. It has been demonstrated that patients with HS associated with cholestasis have disturbed bile acid metabolism, which affects the composition and abundance of gut microbiota. This article reviewed the role and mechanism of bile acid metabolism-gut microbiota interactions in regulating HS associated with cholestasis, with the aim of providing novel treatment strategies for HS associated with cholestasis.