空肠弯曲菌鞭毛III型分泌系统及其效应蛋白的研究进展

Recent advances in the flagellar type III secretion system and effectors of Campylobacter jejuni

摘要:

空肠弯曲菌(Campylobacter jejuni)是最常见的食源性病原细菌之一，在世界范围内广泛流行，感染人和动物表现不同的临床症状和病理变化，特别是家禽感染后不表现任何临床症状，成为人感染的主要来源，解析该菌在宿主体内的感染和定殖机制对其防控具有关键作用。空肠弯曲菌通过鞭毛III型分泌系统分泌效应蛋白，注入宿主细胞内，与细胞内蛋白结合，调控宿主细胞信号通路，改变宿主细胞防御机制，在空肠弯曲菌感染和定殖宿主过程中发挥重要作用。本文就空肠弯曲菌鞭毛III型分泌系统分泌效应蛋白的种类及作用机制，以及在解析该菌致病和定殖方面的作用进行综述，对深入理解空肠弯曲菌的致病机制具有重要意义。

Abstract:

Campylobacter jejuni is one of the most common foodborne pathogenic bacteria worldwide. Humans and animals infected by C. jejuni exhibit different clinical symptoms and pathological changes. Domesticated birds infected by this pathogen did not present clinical symptoms, becoming the main source of human infection. Elucidating the mechanisms of infection and colonization plays a key role in the prevention and control of C. jejuni. C. jejuni secretes effectors through the flagellar type III secretion system (T3SS). The effectors are injected into host cells and bind to intracellular proteins, thus regulating the signaling pathways and altering the defense mechanisms of host cells. Therefore, the effectors play an important role in the infection and colonization of C. jejuni. This article reviews the flagellar T3SS of C. jejuni, the types and mechanisms of T3SS effectors, and the roles of T3SS effectors in infection and colonization of C. jejuni. This review is of great significance for a deeper understanding of the disease-inducing mechanism of C. jejuni.