China has a large livestock and poultry industry. The frequent occurrence of diseases caused by the spread of bacterial pathogens not only cause serious economic losses of this industry but also threaten public health and safety since some pathogens can cause zoonoses. This article provides an overview of the prevalent bacterial pathogens attacking the livestock and poultry industry in China in recent years and summarizes the current development and application of vaccines for domesticated animals in China. This review is expected to provide a theoretical basis for the prevention and control of bacterial diseases attacking the livestock and poultry industry in China.