Abstract:The setting and teaching of interdisciplinary courses is one of the effective ways to cultivate high-quality composite new engineering talents with strong practical ability, strong innovation ability, and international competitiveness. However, at present, it is difficult to achieve effective and satisfactory teaching effect by simply using stacking method of multiple subjects. Based on the development and cross-integration of biological engineering and textile engineering in Jiangnan University, this paper takes the interdisciplinary course Textile Biotechnology as an example to carry out the reform and innovation. We constructed an interactive teaching mode, reorganized multi-dimensional integrated teaching contents, established a cyclic upward teaching quality control system, optimized the assessment system aimed at evaluating students’ interdisciplinary thinking and innovation ability, and adjusted the proportions of teachers with different educational background to form a qualified teaching staff team. Finally, this paper summarizes the practical teaching achievements from the aspects of course development, students’ ability improvement, and teaching staff team building, providing references for improving the teaching effects of interdisciplinary courses.