铁死亡调控代谢功能障碍相关脂肪性肝病的研究进展

Research advances in ferroptosis in the regulation of metabolic dysfunction-associated steatotic liver disease

摘要:

铁死亡是一种近年来发现的新型程序性细胞死亡方式，抑制铁死亡可抑制脂质过氧化，减少肝细胞坏死以及炎症反应，因此，靶向铁死亡通路关键靶标可以作为代谢功能障碍相关脂肪性肝病(metabolic dysfunction-associated steatotic liver disease, MASLD)治疗的新策略。本文综述了铁死亡在MASLD疾病中的作用、分子机制、信号通路及药物应用进展，为研发MASLD治疗药物提供了参考。

Abstract:

Ferroptosis is a novel type of programmed cell death discovered in recent years. Inhibiting ferroptosis can reduce lipid peroxidation, decrease liver cell necrosis, and inhibit inflammatory responses. Therefore, targeting key targets in the ferroptosis pathway may become a new strategy for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). This article reviews the research advances in the roles, molecular mechanisms, signaling pathways, and drug applications of ferroptosis in MASLD, providing a reference for the development of drugs for MASLD.