甾醇C-4甲基氧化酶复合体在甾醇合成中的作用

Role of sterol-C4-methyl oxidase-like in sterol synthesis

摘要:

甾醇在生物体的生长发育、细胞膜构建等方面发挥着重要的作用。甾醇的生物合成是一个复杂的代谢过程，涉及多种酶促反应，甾醇C-4甲基氧化酶复合体在甾醇的生物合成过程中负责去除C-4位的2个甲基，这一过程是甾醇功能化的重要步骤。本文系统综述了甾醇C-4甲基氧化酶复合体(sterol-C-4-methyl oxidase-like, SC4MOL)在甾醇生物合成中的重要作用，特别阐述了甾醇C-4甲基氧化酶复合体的构成、催化机制及其在不同生物体生长发育、抗击病害胁迫等过程中的功能多样性，为深入研究甾醇代谢调控奠定了基础。

Abstract:

Sterols play a crucial role in the growth and development of organisms, as well as in the construction of cell membranes. The biosynthesis of sterols is a complex metabolic process involving multiple enzymatic reactions. The removal of two methyl groups at the C-4 position by the sterol-C4-methyloxidase-like (SC4MOL) is an important step in sterol functionalization. This paper provides a systematic review of the critical role of SC4MOL in sterol biosynthesis. It specifically elaborates on SC4MOL in terms of the composition, catalytic mechanism, and functional diversity across different organisms in processes such as growth, development, and resistance to diseases and stress. The review lays a foundation for further research into the regulation of sterol metabolism.