工程化微藻的药物递送研究进展

Research progress of engineered microalgae in drug delivery

摘要:

微纳米材料在药物递送领域的应用日益受到关注，微藻作为一种具有优秀生物相容性的光合生物群，在该领域存在天然优势。微藻普遍具有易加工的生物质骨架和优秀的光合活性，部分种属还具备一定的自主运动能力，工程化后可用于优化药物递送，并通过原位产氧实现辅助治疗。本综述梳理了工程化微藻在药物递送领域的研究进展，介绍了其临床转化的技术挑战和困难，为微藻的生物医药设计及应用提供了参考。

Abstract:

The application of micro-nano materials in drug delivery has attracted increasing attention. As a photosynthetic group with excellent biocompatibility, microalgae have inherent advantages in this field. These organisms usually show easy-to-process biomass skeletons and remarkable photosynthetic activity, and some species have autonomous mobility. The engineered microalgal system optimizes drug delivery through programmable modifications and achieves auxiliary therapeutic effects through in-situ oxygen generation. This review summarizes the research progress in the use of engineered microalgae for drug delivery, discusses the technical challenges associated with their clinical translation, and provides insights for the design and biomedical application of microalgae-based platforms.