谷胱甘肽生物合成研究与产业化进展

Advances in glutathione biosynthesis and industrialization

摘要:

谷胱甘肽是一种含有巯基的三肽化合物，广泛存在于动物、植物和微生物中，具有抗氧化、解毒等功能，应用于医药、食品、化妆品、饲料等领域。近年来，随着绿色生物制造快速发展，谷胱甘肽产业化升级已经成为研究热点。本文阐述了谷胱甘肽的主要生理功能及应用领域，综述了谷胱甘肽的生物合成研究与产业化进展，探讨了提升发酵法与酶法合成产量的策略，阐述了谷胱甘肽生产的新技术、新工艺，梳理了谷胱甘肽产业化发展现状，并展望了谷胱甘肽生物合成的研究方向，为谷胱甘肽产业转型升级和绿色发展提供了新思路。

Abstract:

Glutathione is a thiol tripeptide widely existing in animals, plants, and microorganisms, showing antioxidant and detoxifying functions. It is used in the multiple fields such as pharmaceuticals, food, cosmetics, and feed additives. In recent years, with the rapid development of green biomanufacturing, the industrial upgrading of glutathione production has become a research hotspot. This paper introduces the main physiological functions and application fields of glutathione and reviews the research progress in glutathione biosynthesis and industrialization. Furthermore, this paper summarizes the emerging technologies and processes of glutathione production, reviews the commercial development of glutathione, and proposes the future development directions, with the aim of facilitating the industrial upgrading and green development of glutathione.