Abstract:[Objective] To identify the distribution of avian influenza virus subtypes among domestic ducks in eastern China. [Methods] One hundred and eighty avian influenza viruses isolated from domestic ducks between 2002 and 2006 were tested for their Hemagglutinin subtypes, and 88 of them were followed by monitoring for Neuraminidase (NA) subtypes. [Results] At least 9 HA subtypes and 6 NA subtypes, which constituted 13 subtypes of avian influenza viruses in domestic ducks, including H1N1, H3N1, H3N2, H3N8, H4N6, H5N1, H5N2, H6N2, H6N8, H8N4, H9N2, H10N3 and H11N2, were circulating in eastern China in recent years. [Conclusion] Multiple subtypes of avian influenza viruses were distributed among domestic ducks in eastern China in recent years. The surveillance and prevention of avian influenza viruses in domestic ducks must be strengthened.