Antagonism of pyroptosis by porcine deltacoronavirus

Abstract:

Porcine deltacoronavirus (PDCoV), an emerging virus globally prevalent, causes watery diarrhea, vomiting, and dehydration of newborn piglets, posing severe economic losses in the swine industry. Moreover, with the characteristic of cross-species transmission, PDCoV can infect human and farmed animals, posing a serious threat to human health. Pyroptosis is a form of programmed cell death mediated by members of the Gasdermin family, which plays a role in defending and eliminating viruses. Coronaviruses, however, have developed precise strategies to antagonize pyroptosis and evade immune responses. This review expounds the biological characteristics of PDCoV, the process of pyroptosis, and the antagonism of Gasdermin D-mediated pyroptosis by PDCoV, aiming to enrich the knowledge about the antagonism of immune responses by PDCoV and lay a theoretical foundation for the prevention and control of this virus.