Research progress in the relationship between gut microbiota and Parkinson's disease

Abstract:

Parkinson's disease is a common neurodegenerative disorder that seriously threatens the health of middle-aged and elderly individuals.However,the pathogenesis of Parkinson's disease is not fully understood.Recent studies have shown that gut microbiota plays an important role in the occurrence and development of Parkinson's disease.Gut microbiota and its metabolites influence the intestinal mucosal barrier,neuroinflammation,endocrine system,and other aspects through the microbiota-gut-brain axis,thereby participating in the occurrence and development of Parkinson's disease.Gut microbiota can be regulated by various methods such as probiotic supplementation,fecal microbiota transplantation,dietary adjustments,and traditional Chinese medicine interventions,being an important target for the prevention and treatment of Parkinson's disease.This article reviews the possible mechanisms of gut microbiota being involved in the occurrence of Parkinson's disease and further discusses the current status of prevention and treatment of gut microbiota dysbiosis.