Research progress in protein persulfidation

Abstract:

Persulfidation plays a role in protein functioning and signaling, maintaining the physiological and metabolic balance of cells, protecting cells from oxidative stress, and regulating sulfur homeostasis. This article summarized the internal relationship of hydrogen sulfide, reactive sulfur species, and cysteine metabolism, expounded the mechanism of sulfur homeostasis regulation, and introduced the role of persulfidation in microbial sulfur homeostasis, providing new thoughts for the future research.