Advances in the characterization and function of UL24 of α-herpesviruses

Abstract:

The α-herpesviruses are a large class of enveloped double-stranded DNA viruses characterized by neurotropic infection and latent infection, posing a serious threat to human and animal health. The α-herpesvirus genome encodes a variety of proteins. UL24, a major virulence gene of α-herpesviruses, encodes a highly conserved protein and play a key role in regulating viral infection. This paper introduced the basic characteristics of UL24 and the encoded protein and summarized the regulatory roles of UL24 in the virus assembly, replication, infection, pathogenicity, and inhibition of host innate immunity, aiming to provide a theoretical reference for understanding the functions of α-herpesvirus proteins and further preventing and controlling α-herpesvirus infection.