Application of functional metabolomics in microbiological studies

Abstract:

Functional metabolomics studies the functions of differential metabolites and related proteins, enzymes, and genes by metabolomics tools, in vitro and in vivo experiments, and molecular techniques based on the discovery of key metabolites, so as to reveal the molecular regulation mechanism in organisms. Being capable of accurately identifying the key regulatory metabolites and the related genes or enzymes, functional metabolomics has received extensive attention in the prevention and control of microorganism-induced diseases and the industrial production. This article introduces the research process, methods, and platforms of functional metabolomics and the application of this technology in microbial research, with focus on the metabolic characteristics, regulatory targets, and related prevention and control strategies of eukaryotes, prokaryotes, and viruses. Finally, we put forward the problems and challenges in the research of functional metabolomics, aiming to provide new ideas for the follow-up study and the development of functional metabolomics.