Molecular mechanism of intracellular pathogenic bacteria invading host cells

Abstract:

Intracellular pathogenic bacteria can invade the host cells and survive and reproduce in the cells. They infect host cells by adhesion, invasion, and survival, finally causing damage to the host cells. Studies have demonstrated that most intracellular pathogenic bacteria are passively ingested by phagocytes. With the development of molecular biology and immunology, increasing intracellular pathogenic bacteria have been proved to actively invade the host cells and evolve a variety of ways to regulate the host cell signaling pathways for escaping cellular immunity. We provided a brief overview of the common molecular mechanisms of intracellular pathogenic bacteria invading the host cells. Further, we introduced the invasion strategies adopted by common intracellular pathogenic bacteria and summarized the main research advances in recent years.