Application of carbohydrate-binding modules in degradation of polysaccharides

Abstract:

Carbohydrate-binding module (CBM) are important components of carbohydrate-active enzymes. CBMs recognize and bind to specific polysaccharides (substrates) to increase the concentration of catalytic domains near the substrates and improve catalytic efficiency, facilitating the degradation of macromolecular compounds such as cellulose, xylan, chitin, and xanthan. The substrate-binding characteristics of CBM vary because of the different sources or structures. This paper summarizes the studies of CBM in recent years from the aspects of family, structure, and function, especially the application in the degradation of polysaccharides and the modification of glycoside hydrolases.