Abstract:A carefully curated group of microbial strains known as probiotics are "live microorganisms that, when administered in adequate amounts, confer a health benefit on the host". The well-known microbe with prebiotic properties include traditional probiotics:lactic acid bacteria, Saccharomyces, etc., and the next generation probiotics:Faecalibacterium prausnitzii, Bacteroides fragilis, Akkermansia muciniphila, Prevotella copri, etc.. Probiotics and the health of humans are closely related. To regulate the host's health, these bacteria can either trigger the gastrointestinal response through the stomach or can directly affect other organs like the mouth, vagina, and skin. As a result, they are often utilized in food production, agriculture, animal husbandry, and medicine. They are also effective instruments for enhancing host health. In order to provide references for the research on the development and application of probiotics resources, this paper reviewed the development and application of traditional probiotics like lactic acid bacteria and the next-generation of probiotics like Akkermansia muciniphila. It also summarized the potential of these probiotics in food production, disease treatment, and agricultural production, and prospected the development trend of probiotics resource research and application, in order to provide reference for the research on the development and application of new and old probiotics.