Relationship of Akkermansia muciniphila and the metabolites short chain fatty acids with intestinal mucosal barrier in ulcerative colitis

Abstract:

Ulcerative colitis (UC) is a life-long refractory disease with high incidence worldwide. Akkermansia muciniphila (A. muciniphila) and the metabolites short chain fatty acids (SCFA) have been found to protect intestinal mucosal barrier in UC, but the specific mechanisms fail to be summarized. Therefore, we analyze the research on the mechanical, chemical, immune, and biological barriers of intestinal mucosa and discuss the mechanisms of A. muciniphila and SCFA on intestinal mucosal barrier, hoping to provide a new perspective and mindset for the study of the pathogenesis and therapy of UC.