Research progress in the antibiotic resistance of giant panda-derived bacteria

Abstract:

Antibiotic-resistant bacteria and antibiotic resistance genes have become new environmental pollutants causing public health problems in the world. The antibiotic-resistant bacteria, especially multidrug-resistant bacteria, has received increasing attention in clinical medicine, animal breeding, and environmental transmission. However, there are few studies about the antibiotic resistance of bacteria in wild animals such as giant panda (Ailuropoda melanoleuca). Giant panda (Ailuropoda melanoleuca) is recognized as a rare wild animal in the world and its population is vulnerable to a variety of diseases, especially intestinal bacterial diseases. With the increasing use of antimicrobials in disease prevention and control, the harm of antibiotic resistance is becoming more and more apparent. By reviewing the research reports on the antibiotic resistance of giant panda-derived bacteria, we introduced the phenotypes, genotypes, and mechanisms of antibiotic resistance as well as the horizontal transmission mechanisms of the bacteria. This review aims to provide a basis for the prevention and control of antibiotic resistance and the reasonable application of antibiotics in clinical practice, so as to facilitate the ex situ conservation of giant panda.