Signal sensing of engineered bacteria in microbial therapy and its application in biomedicine

Abstract:

In recent years, microbial therapy based on the fact that microorganisms can provide health benefits has created new opportunities for the diagnosis and treatment of diseases. Studies have demonstrated that oral administration of Lactobacillus lactis, Escherichia coli, and Bifidobacterium can assist in the treatment of a variety of diseases. In microbial therapy, engineered bacteria have attracted much attention owing to their specific functions. They can either assist in diagnosis by sensing specific signaling molecules in the disease environment, or target the specific signals of the disease site and initiate their expression systems to release specific molecules for precise treatment. This paper reviewed the sensing systems of engineered bacteria for different signaling molecules and the application of the sensing systems in biomedicine.