Research progress in the mechanism of probiotics inhibiting Helicobacter pylori

Abstract:

Helicobacter pylori (Hp) plays a role in the pathogenesis of gastric diseases and is one of the key factors leading to gastritis, gastric ulcer, and even gastric cancer. With the continuous increase in the positive detection rate of Hp in patients with gastric diseases, scientists have achieved certain progress in the research on the association between gastric diseases and Hp. The eradication therapy for Hp-positive patients and the antibiotic resistance of Hp have attracted increasing attention. Probiotics, as relatively safe natural microorganisms, have great research potential and significance for their functions of inhibiting Hp and improving gastric health. This review summarizes the pathogenic mechanism of Hp and the pathogenicity of different genotypes, and then elaborates the mechanism of probiotics inhibiting Hp. It is recommended that the treatment of Hp infection should combine probiotics with conventional therapies, which will not only increase the eradication rate of Hp but also reduce the side effects associated with treatment.