"Microbiota-gut-brain" axis-mediated host appetite regulation

Abstract:

The central nervous system and peripheral hormones jointly regulate the appetite of humans and animals.In recent years,it has been verified that the composition and changes of gut microbiota affect the host՚s appetite through multiple pathways.Intestinal bacteria can secrete and produce a large number of functional metabolites,such as short-chain fatty acids,secondary bile acids,and amino acid derivatives.In addition,gut microbiota can also affect the nutritional perception of the digestive system,delivery of intestinal vagus signals,secretion of intestinal hormones,among others,which are related to the appetite.Therefore,it is new strategy for improving host՚s appetite to clarify the mechanism of bacteria's regulation of appetite and perform targeted regulation and reorganization of gut microorganisms,which is helpful for the diagnosis and treatment of anorexia,bulimia,and other related diseases.