Research progress of lanthipeptides from Actinomycetota

Abstract:

Lanthipeptide are a group of ribosomally synthesized and post-translationally modified peptides (RiPPs),containing rare structure like thioether cross-links termed lanthionines (Lans) or methyllanthionines (MeLans).Recently,lanthipeptides that originated from the phylum Actinomycetota have been the research hotspot due to their outstanding antimicrobial activities and unusual bioactivities.This review focused on lanthipeptides produced by Actinomycetota,with special attention paid to their unique structure and property.Further discussion involved developing lanthipeptide of Actinomycetota origin to meet practical requirement through biological and chemical modifications of known lanthipeptides,as well as genome mining strategies for the discovery of novel lanthipeptides.Lastly,future application potential of lanthipeptide derived from Actinomycetota were summarized and prospected.