Advance in collateral sensitivity in drug-resistant bacteria

Abstract:

Antibiotic resistance is one of the global conundrums. Multi-drug resistant (MDR) bacteria-associated infections pose a great threat to the health of both human and animals. Collateral sensitivity is a phenomenon that the bacteria developed resistance to one antibiotic display increased susceptibility to a second antibiotic. Collateral sensitivity has been intensively explored to restrict and/or reverse the evolutionary trajectory of resistance bacteria in the past years. This review mainly focuses on the concept, phenotypes, and molecular mechanisms of collateral sensitivity, to shed light on the development of alternative approaches to treating MDR bacteria.