Research progress of detection technology of Helicobacter pylori and beyond

Abstract:

Helicobacter pylori induces the incidence and development of many human gastrointestinal diseases via various virulence factors. Due to the lack of commercial vaccine and multi-drug resistance, it is difficult to eradicate this pathogen. Therefore, accurate detection technology is the key to prevent H.pylori infection and an important means of evaluating the treatment effect. The detection methods mainly include urea breath test, rapid urease test, stool antigen test, serological test, endoscopy, histopathologic examination, polymerase chain reaction, and bacteriological culture, each having specific strengths and weaknesses in clinical application. In the absence of an agreed-upon “gold standard” forH.pylori detection, we reviewed H.pylori detection techniques, analyzing their advantages and limitations. Particularly, we summarized the advantages of accurate, rapid, and convenient detection techniques in epidemiological investigation, aiming to provide a scientific reference for clinical application of and research on them.