Research progress on the mechanism of the repair of skin photoaging by probiotics

Abstract:

The skin, the largest organ of the human body, is the first defense line of the immune system. Aging of the skin may lead to dysfunction and weakened protection for our body, causing a series of health problems. Lights, especially the ultraviolet, may accelerate skin aging and destroy our skin barrier. Researchers have demonstrated that ultraviolet can directly damage the DNA and RNA in the skin cells and induce the generation of reactive oxygen species, leading to lipid peroxidation, extra-cellular matrix degradation, and inflammation, all of which ultimately accelerate skin photoaging. Growing evidence has proved the importance of microbiome to skin health, and probiotics may modulate the skin ecology and postpone skin aging through generating anti-oxidative metabolites, inhibiting the activities of matrix metalloproteinases, and reducing inflammatory cytokines. In this review, we summarized the mechanisms of skin photoaging as well as the cutting-edge studies of probiotics against skin photoaging and discussed the potential application of probiotics, aiming to provide a reference for the application of probiotics in the alleviation of skin photoaging.