Research progress of the interaction between antibiotics and bacteria based on metabolomics

Abstract:

Antibiotic killing is a complex physiological process. The downstream metabolic changes of antibiotic-target interactions are closely related to antibiotic efficacy. Bactericidal antibiotics speed up the death process by perturbing the bacterial metabolism, which also influences the antibiotic efficacy. Metabolomics provides comprehensive metabolic information for monitoring the changes of bacterial metabolism under the action of antibiotics. Here we review recent metabolomics-driven studies on the interaction between antibiotics and bacteria, intending to provide a reference for the development of antibiotic adjuvants to enhance the antibiotic efficacy.