Research progress on Bacillus subtilis surface display technology for mucosal vaccine

Abstract:

Bacillus subtilis was favored by researchers attributing to the excellent probiotic properties and strong stress resistance of spores. Owing to the special structure and unique physiological characteristics, the spores are an ideal place for foreign proteins such as enzymes and immunogens to anchor. B. subtilis spore surface display is one of the methods to express foreign proteins with high activity and stability. This article mainly reviewed the strategies and application prospects of displaying antigen proteins on the surface of B. subtilis spores to produce mucosal vaccines.