Research progress on regulating tumor immune escape mechanism of edible and medicinal fungal polysaccharides

Abstract:

Polysaccharides are the main natural bioactive components of edible and medicinal fungi to regulate the immune function of the body from multi-level and multi-target. Early studies focus on the anti-tumor mechanism of edible and medicinal fungi polysaccharides by enhancing the immunity of the body to inhibit tumor cells. However, recent studies show that these polysaccharides can regulate the tumor microenvironment, restore the ability of monitoring tumor and tumor microenvironment, enhance tumor-antigen-specific immune responses ability of the body to the tumor microenvironment, so as to give to inhibit and kill tumor. Our previous studies also show that edible and medicinal fungi polysaccharides can positively increase the number of immune cells in the peripheral blood of tumor mice, promote the infiltration of immune cells into the tumor microenvironment, help the body recognize and kill tumor cells, regulate the tumor microenvironment. Here, we summarize the biological activity of edible and medicinal fungal polysaccharides as immunomodulators in inhibiting tumor immune escape, combined with the tumor microenvironment to discuss their relationship with tumor immunity, mechanism of action, and their role in tumor treatment, to provide new ideas for edible and medicinal fungal polysaccharide immunotherapy.