Research progress on the colonization resistance of intestinal flora to carbapenem-resistant Enterobacteriaceae

Abstract:

The colonization of carbapenem-resistant Enterobacteriaceae (CRE) in the intestinal lumen usually precedes or coexists with CRE infection. The intestinal flora and host normally interact with the colonized CRE to achieve a stable equilibrium state. When dysbacteriosis happens, the intestinal flora losses its resistance to the colonized CRE, increasing the risk of CRE infection. A large number of studies suggest that the resistance of intestinal symbiotic flora to the colonization of CRE can not only prevent infection, but also reduce the risk of mutual transmission among patients exposed to the medical environment. To provide a new idea and method for prevention and control of CRE infection, we studied the prevalence of CRE，the colonization mechanisms of Enterobacteriaceae, and the mechanisms of colonizing resistance to CRE of intestinal flora.