Viral factory: a critical site for virus replication

Abstract:

Several viruses replicate and assemble in specific intracellular compartments, known as viral factories. Currently, with the continuous improvement of the research level, several studies have revealed the structure and formation of the viral factories to some extent. After entry, viruses can recruit cell and viral components in which they assemble and mature. Cell membranes and cytoskeleton participate in the biogenesis of viral factories, and some of them must be supplied with energy by mitochondria. Besides characteristics of viral factories mentioned above, the structure and pattern of them will continue to change as the viruses replicate. This article reviews the structure, organelle recruitment, structural transformation and movement of macromolecular complexes.