Advances in biosynthesis of fluorinated products

Abstract:

Fluorine is a kind of halogen with special properties. Fluorine-containing organic substances can be widely used in bioorganic chemistry, medicinal chemistry, biomaterial science and other fields. Despite innovation of synthetic C-F bond forming methods, selective fluorination is still very challenging. Therefore, it is necessary to use fluorine biochemical methods to selectively introduce fluorine into molecules with diverse structures, but few methods can incorporate fluorine into bioactive molecules with complex structures. Therefore, we review here the discovery of fluorinated natural products and fluorinases in nature, the synthetic pathway of fluorinated natural products, the significance of fluorinated natural product synthesis mechanism, the evolution of fluorinases and the synthesis of fluoride, and the application of fluorinases and fluoride. This review will provide information for fluoride biosynthesis and promote the industrialization process of fluoride biosynthesis.