Abstract:As a key post-translational modification involved in regulation of gene expression, protein phosphorylation plays critical roles in bacterial physiological processes. Here we summarize the types of phosphorylation modification in bacteria, two-component signal transduction, tyrosine phosphorylation as well as serine/threonine phosphorylation, and discuss the regulatory mechanisms and functions of phosphorylation modifications in bacterial cellular processes in recent years. This review is helpful to understand the phosphorylation regulation of bacterial post-translational modifications and its relationship with the control of bacterial infections in the future.