Abstract:As a naturally stable disaccharide, the protective function of trehalose on the activity of organisms under adverse conditions has attracted a wide range of research interests, and also has good application value and potential. This paper focuses on the important model microorganisms and industrial applied yeast, combined with the latest progress in the research of omics, and summarizes the new progress in the research of endogenous trehalose from the aspects of trehalose metabolic pathway, trehalose metabolism and transcription characteristics under stress conditions, and the strategy of improving intracellular trehalose.