Advances in biosynthesis of proteasome inhibitor syrbactins

Abstract:

Syrbactins are microbial natural products, mainly composed of syringolins, glidobactins, cepafunins and luminmycins. At present, several biosynthetic gene clusters of syringolins and other compounds have been cloned, sequenced and heterologously expressed. These studies revealed that, despite the structural differences between syrbactins, they are synthesized in vivo in a similar mode and share a NRPS-PKS hybrid assembly biosynthetic pathway for the formation of their core skeletons. They have drawn continuous research attentions due to the irreversible proteasome inhibition activity. This review focuses on the research advances in syrbactins and highlights their structure, biosynthesis and mode-of-action.