Application of omics technology on Corynebacterium pseudotuberculosis pathogenicity analysis

Abstract:

Corynebacterium pseudotuberculosis is an interesting bacterium due to its great zoonotic potential and because it causes considerable economic losses worldwide. The rapid development of omics technology has promoted the study of C. pseudotuberculosis pathogenicity. A total of 72 C. pseudotuberculosis genome sequences were obtained by genome sequencing analysis, and the structure, evolution and pathogenicity differences of C. pseudotuberculosis biovar equi or biovar ovis were identified. Based on the proteomics study, proteins such as phospholipase D (PLD), serine protease (CP40) and neuraminidase H (NanH) were found to be related to C. pseudotuberculosis physiology, toxicity and immunity, and other unknown functions. With the transcriptomics, it was found that defense against oxidative stress, adhesion and regulation were most typical in the gene expression difference in harsh environments such as high osmotic pressure, heat shock or acidic conditions. In this paper, we analyzed the C. pseudotuberculosis Xuanhan strain (XH02) we obtained with comparative genomic and SNP evolution, and the application of proteomics and transcriptomics in C. pseudotuberculosis pathogenesis was reviewed.