LC3-associated phagocytosis and microbial infections

Abstract:

LC3-associated phagocytosis (LAP) is an efficient process for the phagocytosis and degradation of invading pathogens. Recently, many studies show that LAP plays a very important role in the elimination of pathogenic microorganism, and its mechanism is different from the conventional phagocytosis and autophagy. Upon the extracellular stimulation, the activation of some autophagy related proteins in host cells induces the recruit of LC3 to the single membrane of phagosome, which promotes the efficiency of phagocytosis and killing of the pathogens. Different pathogens have different mechanisms to cope with the killing of LAP. The general mechanism of LAP, different responses to LAP to various pathogens and the research progress in recent years are reviewed in this paper.