Roles of Salmonella effectors in manipulating host cell function

Abstract:

Salmonella is an intracellular bacterial pathogen that infects both humans and animals. After a long time of hard struggle, Salmonella has evolved numerous mechanisms to evade host immune defenses, and finally accomplished the process of invasion and replication. Although some of the host targets manipulated by Salmonella effectors have been identified, the interaction between Salmonella and host cells remains unclear. This review summarizes the functions and mechanisms of Salmonella effectors in regulating the host cell signaling pathways, including cytoskeletal changes, inflammatory responses, membrane modifications and vacuolar trafficking.