Advances in studies of translocation of effector by bacterial type 3 secretion system

Abstract:

Type 3 secretion system, as one of the secretion systems for Gram-negative bacterial, plays an important role in the pathopoiesia of Gram-negative bacteria. Bacteria can use T3SS as a canal that directly translocates effectors to host cell. Effectors in host cell manipulate a subset of signaling pathways of host cell to promote bacterial colonization in cells. The translocation of effectors is regulated by two factors, one is the signal sequences of effector, and the other is the regulation of T3SS-associated proteins. In this article, we review recent advances in studies on the constitute of T3SS and the mechanism of effectors translocation.