Progress in archaeal protein kinases study

Abstract:

Phosphorylation is one of the main types of protein post-translational modifications, which can be catalyzed by protein kinase, phosphotransferase, and phosphorylase. Among them, reversible protein phosphorylation mediated by protein kinases/phosphatases is an important mechanism of signal transduction in cells and plays regulatory roles in the processes of DNA replication, transcription, protein translation, and DNA repair. The study of protein kinases in archaea is still at the initial stage. Although phosphoproteomics studies showed that there are a large number of phosphorylated proteins in archaea, their specific enzymes and regulation mechanisms involved are still unclear. In this review, we summarized the putative functions of the protein kinases involved in the cellular processes including DNA metabolism, cell metabolism, cell cycle and cell mobility mechanism. Finally, we also proposed the perspectives of studies on archaeal protein kinases.