Catalysis,engineering and application of amino acid dehydrogenases

Abstract:

Amino acid dehydrogenases catalyze the reversible oxidative deamination of amino acids and reductive amination of keto acids, with thermodynamic equilibrium favoring the reductive amination direction. This is one of the most attractive methods for the synthesis of amino acids with high atomic economy and less environmental impact. This review addresses recent advances in studies on reaction mechanism, molecular modification and synthetic applications of amino acid dehydrogenases.