The strategies and research progresses of rational improvement of the yield of microbial drug-A review

Abstract:

Microbial drug is a large family of small molecules with unusual structural features and potent bioactivities. The production of microbial drug is crucial for its subsequent development and cost. Traditional breeding strategies for microbial drug production have been demonstrated to be remarkably effective, but they have also indicated the drawback of exceptional randomness and high cost. Synthetic biology has recently promised a revival for the rational enhancement of microbial drugs. In this review, we mainly discuss the recent progress from the aspects of promoter engineering, precursor supply, genome shuffling and etc., to delineate the application of the synthetic biology strategies to enhance the production of the microbial drugs, particularly, produced by actinomycetes.